2016 Volume 27 Issue 2 Pages 293-297
In the prospective, multicenter, observational Bleeding with Antithrombotic Therapy (BAT) Study, dual antithrombotic therapy was independently related to an increased risk of bleeding events in Japanese patients with cerebrovascular or cardiovascular disease. In its sub-study, an increase in blood pressure levels during antithrombotic medication was positively associated with development of intracerebral hemorrhage, suggesting the importance of adequate blood pressure control for avoiding intracerebral hemorrhage. The retrospective observational study performed by the same investigators (the BAT-Retrospective Study) demonstrated that prior medication with antiplatelet agents, warfarin, or both was predictive of hematoma enlargement and early death after intracerebral hemorrhage.
