Cerebral blood flow of neurodegenerative disease

Abstract

We analyzed the characteristics of regional cerebral blood flow (rCBF) in genetically confirmed spinocerebellar ataxia type 6 (SCA6) patients. Decreased rCBF was found in the cerebellum and was associated with duration of illness. We also analyzed the modification of tau in cerebral ischemia and reperfusion (I/R) in rats. Both 4-repeat and 3-repeat tau isoforms are heperphosphorylated in cerebral I/R, similar to Alzheimer’s disease.