The role of sterile inflammation in ischemic stroke

Abstract

The post-ischemic sterile inflammation will be a hopeful therapeutic target for ischemic stroke. Damage-associated molecular patterns (DAMPs) which are released from dying brain cells activate infiltrating immune cells through pattern recognition receptors. Inflammatory cytokines produced from activated macrophages/neutrophils induce T-cell-mediated secondary ischemic damages in the delayed phase of ischemic stroke. DAMPs are removed from ischemic brain through scavenger receptors, MSR1 which is highly expressed by repairing macrophages, for the resolution of cerebral post-ischemic inflammation. Thus, DAMPs are important regulators of sterile inflammation after ischemic stroke.