Abstract
KiBank is a database of inhibition constant (Ki) values with 3D structures of target proteins and chemicals. It is accessible at http://kibank.iis.u-tokyo.ac.jp/. The contents of target proteins were nuclear and membrane receptors, enzymes, and, now, newly include transporters, ion channels and ion pumps. The numbers of data were updated to 16,084 Ki values, 101 target proteins (310 subtypes), and 9,279 chemicals in April 2006. Target proteins and the numbers of Ki values for corresponding chemicals were listed. Examples are shown for applications of KiBank for drug development.
