Abstract
Purpose: The warm ischemic period following cardiac arrest damages the lungs. N-Methyl-1-deoxynojirimycin (MdNM) can preserve glycogen and reduce myocardial infarct size in rabbit heart. We tested the hypothesis that MdNM may reduce ischemia reperfusion injury of the lung using an in vivo rat model.
Methods: We administered MdNM (30mg/kg) or saline intravenously. We clamped the left lung hilus for 60 minutes and then reperfused it for 60 minutes. We measured baseline arterial oxygen tension and calculated the percent recovery of the oxygen tension every 10 minutes during reperfusion.
Results: The percent recovery of oxygen tension was significantly higher (p<0.05) in the MdNM group (n=6) than in the control group (n=6) at the end of the 60 minutes of ischemia and during the initial 30 minutes of reperfusion. The oxygen tension was still higher in the MdNM group at the end of the 60-minute reperfusion, but the difference was not significant.
Conclusion: Preischemic treatment with MdNM had a partial but significant protective effect against ischemia reperfusion injury of the lung.
