Abstract
The effects of edaravone on reperfusion-induced ventricular arrhythmias in the isolated perfused rat heart were investigated. Using Langendorff perfusion-system, each isolated rat heart was perfused with Krebs-Henseleit buffer, containing various concentrations of edaravone(0, 10, 25, 50, 75, 100, 150μM) for 10 minutes. After that, each heart was subjected to regional ischemia(11min) and reperfusion(3min). The result showed that edaravone had no significant effect on coronary flow and heart rate at any time during the experiment. At 25, 75, 100μM of edaravone, the incidence of reperfusion-induced ventricular fibrillation(VF) was significantly reduced from the control value(p<0.05). At 25μM of edaravone, the incidence of sustained VF was significantly reduced from 92% to 50%(p<0.05).
Edaravone is suggested to have a protective effect against reperfusion-induced arrhythmias.
