Abstract
To evaluate the effects of milrinone on the pulmonary hypertension during cardiac surgery, 20 patients who showed pulmonary hypertension after anesthesia induction were studied. Pulmonary artery pressure(PAP), pulmonary vascular resistance(PVR) and hemodynamic parameters were measured before the milrinone infusion(0.5μg/kg/min), and 15min and 30min after the milrinone infusion. Six out of 20 patients were excluded because of decreases in systemic systolic blood pressure by more than 30%. In the other 14 patients, mean artery pressure(from 76±13 to 67±11mmHg), PAP (from 34±12 to 23±3mmHg), central venous pressure(from 12±5 to 8±6mmHg), and PVR(from 440±112 to 194±56 dyne/sec/cm-5) decreased significantly at 30 min after the milrinone infusion. Heart rate(from 79±23 to 98±20rate/min), cardiac output(from 3.4±1.6 to 4.9±2.6L/min) increased significantly at 30min after milrinone infusion. Oxygen saturation of mixed venous admixtures increased significantly at 15min after infusion (from 69±14 to 74±11%). These data suggest that milrinone may be a useful drug for the treatment of pulmonary hypertension during cardiac surgery.
