CIRCULATION CONTROL
Print ISSN : 0389-1844
original articles
Differential stereoselective effects of levobupivacaine, bupivacaine and dexbupivacaine on the heart in isolated rat hearts
Kazuya Urashima, Yoshiro Sohma, Yoshio Ijiri, Shiori Terai, Takashi Umeda, Yuka Kawakami, Takako Nishihori, Yoshihiko Hirotani, Kazuhiko Tanaka
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Keywords: bupivacaine, levobupivacaine, dex-bupivacaine, heart rate, ion
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2005 Volume 26 Issue 2 Pages 140-147

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Abstract
Bupivacaine(BUP) has an advantage over other local anesthetics because of its long-acting sensory anesthesia, but because of its high affinity for the myocardial Na+ channel it can be cardiotoxic. Levobupivacaine(LBUP) is an S(-)-isomer of the racemate BUP, and dexbupivacaine(DBUP) is an R(+)-isomer. LBUP has less neuronal and cardiac toxicity than BUP and DBUP, but DBUP induces more negative chronotropism and arrhythmogenic effects than either LBUP or BUP.
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© 2005 by Japan Society of Circulation Control in Medicine
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