Abstract
The administration of an ultra-short acting β1 blocker has been introduced as a novel method for the treatment of supraventricular tachycardia during cardiac surgery. In the present study, the effect of ultra-short acting β1 blocker, landiolol, on tachycardia during off-pump coronary artery bypass graft was investigated. Landiolol 0.125mg/kg was injected intravenously and landiolol 0.04mg/kg/min was infused continuously for 30 minutes in twenty patients who were scheduled for off-pump CABG and demonstrated supraventricular tachycardia (100bpm<) during the preparation of intra thoracic artery. At 10min after the start of ladiolol infusion, the heart rate was significantly decreased from 112±8 to 98±10bpm and the mean artery blood pressure was significantly decreased from 74±16 to 67±13mmHg. Other hemodynamic parameters did not significantly change during ladiolol infusion. These results may suggest the efficacy of ladiolol for reducing tachycardia during off-pump CABG.
