Abstract
Acute aortic syndrome is responsible for an over-production of inflammatory cytokines, due not only to the bodily onslaught brought about by its clinical condition, but also to the development of systemic inflammatory response syndrome(SIRS), leading to the onset of multiple organ failure and difficulties in postoperative management. In the current study, the efficacy of Sivelestat sodium, a neutrophil elastase inhibitor, was evaluated on sequential organ failure assessment(SOFA) after emergency surgery in acute aortic syndrome. The subjects were 21 patients who developed acute aortic syndrome and underwent emergency surgery between August 2006 and December 2007. Starting the administration of Sivelestat sodium before surgery to patients with acute aortic syndrome could reduce the augmentation of inflammatory mediator and factors related to the coagulation-fibrinolysis system. Although SOFA score and lung injury scores were not significantly different between pre-operative and post-operative use of Sivelestat sodium, DIC was significantly suppressed in the pre-operative use of Sivelestat sodium were effectively suppressed in the pre-operative use as compared with the post-operative use. It is suggested that pre-operative initiation of Sivelestat sodium may be effective for organ protection in acute aortic syndrome.
