The Efficacy of Carperitide in a Patient with Severe Renal Dysfunction Undergoing Off-Pump Coronary Artery Bypass Grafting: A Case Report

Abstract

A 76-year-old man presented to our hospital with chest pain and dyspnea. Coronary angiography revealed a 90% stenosis in the left main trunk, 90% stenosis in the left circumflex artery, and total occlusion in the right coronary artery. He was also diagnosed as having severe renal dysfunction with serum Cr 3.93mg/dl, eGFR 12.5ml/min/1.73m² and Ccr 19.3ml/min. He underwent OPCAB, and carperitide was administered during the operation and continued until the 8 POD. The combined therapy of OPCAB and carperitide infusion were effective for protection of renal function during and after the operation. The urine output and renal function were maintained at the same level as the pre-operation values during and after the operation.