Benefits of cardiac microdialysis technique in the cardiovascular research

Abstract

We have applied the microdialysis technique used in neurochemical studies of the brain to the heart. Cardiac microdialysis technique enables us to directly monitor norepinephrine released from cardiac sympathetic nerve endings as well as acetylcholine released from cardiac vagal nerve endings and provides many advantages in the assessment of cardiac autonomic nerve activities 総説 217 and nerve ending functions including reuptake. Moreover, the cardiac microdialysis technique makes it possible to monitor myocardial interstitial concentrations of endogenous substances in the ischemic region continuously during ischemia as well as after reperfusion and locally administer pharmacological agents to the ischemic region through dialysis probes. The cardiac microdialysis technique is a powerful method for the study of pathophysiology during myocardial ischemia- reperfusion.