Abstract
Teratogenic effects of a new non-steroidal anti-inflammatory agent, 6-chloro-5-cyclohexyl-1-indancarboxylic acid (TAI-284) were studied in CF#1 mice by gavage. Indomethacin was used as a reference compound. The results are summarized as follows: 1. When TAI-284 at 10, 30 and 90mg/kg/day or indomethacin at 7.5mg/kg/day were daily given from day 7 to day 15 of gestation, malformations of cervical and thoracic vertebrae and the ribs were induced in the animals treated with 90mg/kg of TAI-284 and (7.5mg/kg of) indomethacin. 2. When the pregnant mice were treated with a single dosing of TAI-284 at 90mg/kg or of indomethacin at 10mg/kg once from day 7 to day 9, the skeletal malformations similar to those induced by the successive treatment as described above were seen in the animals receiving each compoud on day 7 or day 8. 3. Teratogenic effects of other non-steroidal anti-inflammatory agents were reviewed and it was suggested that the skeletal malformation could be induced in mice by an inhibition of the prostaglandin synthesis.
