Cytogenetic Analysis of Mammalian Oocytes as a Tool for Chromosomal Mutagen Screening

Abstract

Cytogenetic analysis of mammalian oocytes is one of the useful methods for the detection of chromosomal mutagenic potential of environmental chemicals. So far, more than 20 chemicals have been examined for the induction of chromosome aberrations on the mammalian oocytes at various stages from dictyotene of the meiosis I to blastocysts. In this paper, these findings were reviewed and some technical aspects of these methods were discussed. Further, this technique of chromosome analysis of mammalian oocytes is thought to have wide applicability in the field of reproductive physiology.