1983 Volume 23 Issue 2 Pages 223-229
The teratogenic susceptibility to thalidomide was compared in Japanese White (JW) and JW-NIBS (NIBS) rabbits. No abortions were found in Group JJ (JW × JW), but they occurred in Groups NN (NIBS × NIBS) and NJ (NIBS × JW) with a higher frequency than in Group JN (JW × NIBS). External head anomalies such as holoprosencephaly, anencephaly and hypoplasia of ala nasi displayed a high frequency in Group NN, but not in Group JJ. In Groups JN and NJ, the frequency of holoprosencephaly and hypoplasia of ala nasi was higher in Group JN than in Group NJ. Anencephaly was found with the same frequency in Groups NJ and JN. Patroclinous sensitivity factors from NIBS males were considered to account for the high frequency of holoprosencephaly and hypoplasia of ala nasi.
