1966 Volume 6 Issue 4 Pages 255-271
Prospective follow-up study was performed on 2,116 prenatal patients whose first visit to our obstetric O.P.D. was at 5th to 8th week of gestation. Every abnormal experience during pregnancy (emesis, genital bleeding, fever, cold, contact with domestic animals, stress, anemia, glycosuria, toxemia of pregnancy, albuminuria), age of patient and weight increase during pregnancy were recorded together with hemoglobin value, blood pressure, albuminuria and glycosuria checked in each prenatal visits. Followings are the result in this study on the associations between maternal abnormal experiences in early pregnancy and congenital malformations. Associations between above experiences during pregnancy and prematures were also studied. As our preliminary comparison of the weight distribution graph of the infants born in 38th week of gestation revealed the entirely similar distributions to those of the babies born in the 39th, 40th, 41st and 42nd week of gestation, the prematures born in 38th week of gestation were also included in the parentheses. The congenital malformations were divided into two groups as follows : Group A : polydactylia or syndactylia (7 cases), cleft palate or lip ( 4 ), defect of one eye ( 1 ), anophthalmus( 1 ), meningocele( 1 ), hydrocephalus due to Arnold-Chiari's syndrome ( 1 ), microcephalus ( 1 ), diaphragmatic hernia ( 2 ), meconium ileus ( 1 ), pyloric stenosis ( 1 ), megacolon ( 1 ) Group B accessory auricle ( 4 ), unequal ear ( 1 ), accessory mamilla ( 1 ), defect of uvula ( 3 ) Frequency of group A & B malformation was 36 in 2,116 cases (1/59), and that of group A only was 27 in 2,116 cases (1/78). The association with maternal abnormal experiences were shown in the tables. The frequency of A & B malformation was shown, and also in parentheses the frequency of A malformation only was shown. From these tables, apparently A malformation seems in creased in the group with genital bleeding, and A & B malformations are more frequent in the group being under
