Abstract
V. Drugs and chemical substances 1) Thalidomide 2) Actinomycin D 3) Streptonigrin 4) Chlorambucil 5) Dextroamphetamine 6) Urethane and hydroxyurea 7) Aflatoxin B_1 8) Purine analogues 9) Methyl salicylate 10) Beta-amino- 11) Trypan blue 12) Others propionitril (BAPN) VI. Zinc deficiency and cadmium VII. Tissue antiserum VIII. Hormone The problems concerning the abnormal development of the heart were discussed and summarized according to the following items: 1. The role of the genome during cardiogenesis in the embryo 2. The patterns of cardiovascular anomalies produced by different agents 3. The relationship between embryonic stage at which agents are administered and frequency of heart anomalies manifested 4. Morphology of the abnormal cardiogenesis in early stages of embryos 5. The relationship between anomalies and chromosome changes in the embryo treated with various agents 6. The relationship between anomalies and lysosome formation in embryonic cells 7. The relationship between anomalies and LDH-isozyme differentiation in early states of embryos
