Toxicologic pathological researches conducted in the Sasaki Institute in order to contribute to the risk assessment/management of chemicals

(1) Findings from researches on a hepatocarcinogenic model of rats fed a choline-deficient, L-amino acid-defined diet

Abstract

Articles in this special program of the journal describe the significance of the risk assessment/management for the assurance and maintenance of human health and welfare, and the importance of toxicologic pathology in such an attempt. The Sasaki Institute (Department of Pathology) has been contributing to the risk assessment/management of chemicals, by doing researches on the detection of toxicity/carcinogenicity of chemicals, the elucidation of its underlying mechanisms, and the influence of chemicals toward particular pathological situations (e.g., carcinogenesis), using animal models extrapolative to the human situations. Among them, this article introduces findings from researches on a hepatocarcinogenic model of rats fed a choline-deficient, L-amino acid-defined diet.