Abstract
1) Premature and newborn infants were given single intramuscular injections of Cephaloridine and' Cephalothin in doses of 25 mg per kg of body weight.
The blood level was highest 30 minutes after injection of Cephaloridine and cause to be low or none at 12 hours, but the level of Cephalothin was highest at 1 hour, coming to be low at 8 hours.
During the first 8 hours of administration of Cephaloridine the high blood level was proportional to the age and the weight of infants. The blood level of Cephalothin decreased more rapidly than that of Cephaloridine.
2 ) In premature and newborn infants 25. 8 to 54. 0% of a dose of Cephaloridine given was excreted in 12-hour uring, but 87. 0% of Cephalothin was excreted.
3) Cephaloridine and Cephalothin are more effe c t ive against Staph. aureus. 86. 8% and 81. 6% of the strains were inhibited by O. 3 9 or less mcg/ml of Cephaloridine and Cephalothin.
4) It appears from the data given above that in premature and/or newb o rn infants, the intramuscular administration of Cephaloridine in doses of 20. 0 to 25. 0 mg per kg body weight every 8 or 12 hours; and that of Cephalothin in the same doses every 6 hours may be more effective than that hereto fore. in use.
