1968 Volume 16 Issue 4 Pages 554-555
The in vitroantibacterial activity of new antibiotic enduracidin against gram positive bacteriae and the clinical therapeutic effect of this antibiotic on gram positive bacterial infections was studied by us.
1. The in vitro sensitivity of enduracidin was measured by serial dilution method with freshly isolat ed strains of Staph. aureus. Most of strains were inhibited by 1. 0 mcg/nil.
2. Seven patients with gram positive 'bacterial infections and mixed infections of gram positive and negative bacteriae were treated with enduracidin. All patients were administered 100 mg of enduracidin intramuscularly once daily and the treatment period was about a week to a month. With respect to the clinical symptoms and clinical examination, enduracidin treatment showed good clinical results. Any side effect was not found by enduracidin therapy.
