INHIBITORY EFFECT OF DOXYCYCLINE ON MYCOPLASMA PNEUMONIAE IN VITRO

Abstract

Inhibitory effect of six tetracyclines was studied on Mycoplasma pneumoniae MAC and six strains. from patients.
Minimum inhibitory concentration was determined with color change of CRANocK's fluid medium, supplemented with glucose and phenol red. Reading was made when the color of drug free liquid medium turned final yellow by the acid production of Mycoplasma.
The mycoplasmostatic effect was observed in the following order: doxycycline, demethylchlortetracycline, methacycline, and chlortetracycline.
The experimental meth od for the mycoplasmostatic effect and its meaning was discussed.