PHARMACOLOGICAL STUDIES ON DOXYCYCLINE
1969 Volume 17 Issue 2 Pages 141-148
Details
1969 Volume 17 Issue 2 Pages 141-148
Pharmacological actions of doxycycline were investigated. The movement of the excised heart of toad and rabbit were inhibited (5 x 10-5 g/ml). Bradycardia took place at the dose of 1 mg/kg. The movement of the excised intestine of rabbit and the tonus of- the excised intestine of guinea pig were stimulated (10-7 or 5 x 10-7 g/ml) and inhibited (10-4g/m1). The excised rabbit ear vessels were constricted (10-5 g/ml) and the permeability of cutaneous vessels were stimulated (100 mcg). Temporary fall in blood pressure (5 mg/kg) and acceleration of respiration (5 mg/kg) were observed in the urethane anesthetized rabbit. Clonic convulsion was observed in the rabbit (injected in cisterna magna). Doxycycline, therefore, has not remarkable pharmacological actions at therapeutic doses.
Doxycycline has less pharmacological actions than tetracycline and some tetracyclines.
