1969 Volume 17 Issue 2 Pages 161-166
On doxycycline, fundamental experiment and clinical application were performed.
1. The minimal inhibitory concentrations of doxycycline against Stap hylococcus aureus and some strains of gram negative bacilli were one half to one quarter of tetracycline.
2. The mice, inoculated with R. orientalis intraperitoneally, w ere treated with oral administration of doxycycline and demethylchlortetracycline. Survival 'days of the mice treated with doxycycline were longer than those with demethylchlortetracycline.
3. The blood peak le vels and half life times of doxycycline at oral dose of 200 mg were little influenced by renal impairment.
4. Fifteen cases of various infections including 1 case of tsutsugamushi disease, 6 cases of pneumonia were treated with oral administration of doxycycline. This drug was effective in 12 cases and partially effective in 3 cases. No side effect excluding gastric irritation was found.
