FUNDAMENTAL AND CLINICAL STUDIES ON DOXYCYCLINE

Abstract

Doxycycline chemically known as a-6-deoxyoxytetracycline was administrated orally, to 26 patients with a surgical infection in our surgical clinic and the observation on clinical effects as well as basic experiments were performed.
We obtained the following results.
This drug was proved to be most effective in 5 out of 26 cases and moderately effective in 19 cases, and not effective in 2 cases. Only the minimal side effects in the alimentary tract were noted and no disturbances of the hepatic or renal functions were found.
This drug showed higher levels in blood and billiary excretion and kept an effective serum concentration for longer period by the oral administration in comparison with other analogous drugs.