1969 Volume 17 Issue 2 Pages 353-359
Antibacterial activity of doxycycline against 170 gram-negative urinary tract pathogens was tested by the plate dilution method and compared to that of tetracycline and oxytetracycline.
Serum level and urinary excretion after a single oral dose of 200 m g were measured, and the urinary excretion decreased in a case with impaired renal function.
And the ratio of the renal tissue level to serum level decreased according to degrees of impaired renal function.
Clinical responses of doxycycline on 13 females with acute cystitis were reported, resulting that excellent response was seen in 8 cases, good in 4 cases and non effective in 1 case.
