EXPERIENCES WITH DOXYCYCLINE FOR THE TREATMENT OF CHRONIC SINUSITIS
1969 Volume 17 Issue 2 Pages 421-423
Details
1969 Volume 17 Issue 2 Pages 421-423
1) Doxycycline (Vibramycin) administered to 37 cases of chronic sinusitis in doses of 100 mg daily for 4 weeks was effective in 8 (21. 6%), fairly effective in 15 (40. 5%), and ineffective in 14 (37. 8%).
The side effects of doxycycline were gastralgia in 2 cases (5. 0%) and glossitis in one (2. 5%). No serious side effect developed.
Peripheral hemato l ogic examinations, urinalysis, and liver functional tests performed before and after administration of doxycycline in 17 cases found nothing abnormal.
2) No particular relationship was present between the bacteria detected from the middle nasal meatus and the effectiveness of doxycycline. This antibiotic was found effective for a broad spectru m of bacterial infections.
3) The minimal inhibitory concentration of doxycycline against 16 strains of coagulase-positive. staphylococci isolated from clinical otorhinolaryngological cases was a little lower than the minimal inhibitory concentration of tetracycline.
