1969 Volume 17 Issue 2 Pages 435-439
Doxycycline, a new antibiotic derived from tetracycline, was administrated orally to 74 patients suffered from diseases of the oral regions. The dose schedule was 200 mg for the initial day, followed by a single 100 mg dose on subsequent days. Seventy-four cases were divided into 2 groups, the one consisted of 50 cases treated for infections of the oral regions, for instance, osteomyelitis, LuDwIo's angina, lymphadenitis and others, and the other one consisted of 24 cases intended to prevent infections after the operation or the traumatic injuries of the oral regions, for instance, excision of tumors, ostectomy, jaw fractures and others. Among the 50 cases of the first group, 9 cases (18%) showed superior result, 27 cases (54%) good result, 9 cases (18%) fairly good result, and 5 cases (10%) proved no effectiveness of doxycycline. The side effects were seen in 9 cases (12. 2%). They were stomach disorder, stomachache, nausea and stomach discomforts.
