STUDIES ON ANTI-TUMOR AGENTS. IV
Effect of TC-17 on Tumor Cells
1970 Volume 18 Issue 2 Pages 184-188
Details
1970 Volume 18 Issue 2 Pages 184-188
Direct action of a potential anti-tumor agents, TC-17 on tumor cells was investigated.
1. The compound showed a marked damaging activity on ascites tumor cells and inhibition of nucleic acids synthesis in HeLa cells with a concentration of 0.05%.
2. The cytolytic activity on tumor cells was more strong and selective than the hemolytic activity on rabbit RBC.
3. Inhibitory activities on the respirations and anaerobic glycolysis of EHRLICH ascites tumor cells. were very weak even at the high concentration of 5×10-3 M (0.59%).
4. The tumor cell damaging activity of the compound was very insufficient in regard to cytocidal activity.
5. Fluorescent staining of tumor cells with TC17 showed that the compound had a strong affinity for intra and extra nuclear nucleoproteins.
