Abstract
1, 2-Bis [5 (or 6) -methoxy-2-benzimidazolyl] 1, 2-ethanediol (BMBID) at a concentration of 35. 4mcg/ ml (10-4M) clearly inhibited the formation of infectious RNA of poliovirus and the incorporation of 14C-uridine into poliovirus RNA. Marked reduction of virus yield and inhibition of plaque formation could be demonstrated when the infectious RNA was infected on HeLa S3 cells in the presence of BMBID, but BMBID did not have any direct inactivation effect on infectious RNA of poliovirus. It is thought therefore that the inhibitory effect of poliovirus growth by BMBID may be due to an inhibition of viral RNA replication.
