1972 Volume 20 Issue 1 Pages 107-113
1) The antibacterial activity of that of Vistamycin is almost the same degree as that of kanamycin (KM) against Escherichia coli, while it is a grade inferior to kanendomycin (KDM). There encountered many resistant strains in Proteus and Pseudomonas.
2) The antibacterial activity of Vistamycin is stronger as the pH of both medium and diluent is higher, and it is better as the inoculum size is smaller. Only a slight difference was observed among the actionties of various media.
3) The test of resistance aquisition of Escherichia coli B resulted that M.I.C. was more than 100 mcg/ml after 4 transfers with Vistamycin. The value is similar to that of KM, and earlier than that of KDM.
4) The blood concentration of Vistamycin reached the peak after 30 minutes, and then decreased gradually. The antibiotic was excreted mostly in urine within 4 hours, and the recovery ratio was high within 6 hours.
5) As for the Vistamycin concentration in organs, it was distinctly higher in kidney, next in lung where as it was small in other organs.
6) Vistamycin was applied therapeutically for the surgical Infections and prophylactically for the postoperative infections. From the results obtained, the effective ratio with Vistamycin was 69.2%.
