Abstract
Sulfamethoxazole-trimethoprim combination product was given to 3 patients with blood dyscrasias (2 patients with acute granulo myeloid leukaemia and 1 patient with aplastic anemia) complicated by bacterial infections and 2 patients with rheumatoid arthritis and cystic kidney complicated by urinary tract infections in a dosage of 2 to 8 tablets daily for 8 to 20 days. Two of the 3 patients with blood dyscrasias responded by defervescence and both patients with urinary tract infections underwent bacteriological cure. Isolated pathogenic organisms were Escherichia coli, Klebsiella and Pseudomonas. A mild skin eruption was recorded on the 11th treatment day in a patient.
