Abstract
The laboratory investigation on a new macrolide antibiotic - mydecamycin was carried out as follows :
1) The result of sensitivity test with 59 strains of Staphylococcus aureus using plate dilution method was similar to those with kitasamycin and maridomycin.
2) In tissue distribution study of the rats and those with fatty liver pretreated by carbon tetrachloride, similar results were obtained and high tissue level was shown in the lung but not in the liver.
3) Further investigation on tissue level in the liver was carried out, and the results seem to indicate essentially lower liver level of the substance than oleandomycin.
4) In in vitro investigation of metabolism using thin layer chromatography depropionated metabolite of the original substance (Ml) was found following incubation with liver homogenate of rat but not with acetone pretreatment.
Similar results has been obtained from the liver of rat pretreated with carbon tetrachloride.
5) In analysis of human urine using thin layer chromatography, Ml, original substance and other unknown metabolites were detected following oral medication.
Clinical investigation study of 22 cases with infectious disease including 6 cases with pneumonia was carried out.
Sixteen cases responded well to the treatment, 3 failed and 3 were unknown. No serious side effect has been observed.
