LABORATORY AND CLINICAL TRIALS OF PROPIONYLMARIDOMYCIN

Abstract

The in vitro test on susceptibility of Staphylococcus aureus to propionylmaridomycin showed MIC between 0.78 and 1.56mcg/ml. MIC of josamycin was also between 0.78 and 1.56mcg/ml. The inhibitory action of propionylmaridomycin was thus found to be similar to that of JM against Staphylococcus aureus.
The serum concentration of propionylmaridomycin showed a peak of 1.1-1.6 mcg/ml at two hours after the administration of 400mg.
Clear inhibition against Staphylococcus aureus 209 P was observed at the 4 fold dilution of the serum sample and slight inhibition was observed even at the 32 fold dilution.
Propionylmaridomycin was effective in all cases with upper respiratory infections such as pharyngitis and bronchitis. The effect was similar to that of other macrolide antibiotics.
No noticeable side reactions but one anorexia were observed.