1973 Volume 21 Issue 5 Pages 1099-1106
Studies were done on basic and clinical studies on propionylmaridomycin.
1) Blood level and urinary excretion
The peak blood level of propionylmaridomycin reached about 0.4 mcg/ml one hour after oral administration of 600 mg.
As low as 0.8% of the activity was excreted in urine for 6 hours.
2) Concentration in bile Biliary concentration of this macrolide antibiotic revealed comparatively high level of 275 mcg/ml in healthy adults, while that of patients with renal impairment revealed somewhat low level.
The metabolites mostly consisted of 4″-deacylmaridomycin and unknown substances. The unknown substances increased in the patients with malfunction of biliary excretion.
3) Concentration in pus
The concentration of the activity in pus was about the same as that in the blood. 4″-Deacylmaridomycin was the main metabolite in pus.
4) Antibacterial activity
The susceptibility pattern of 26 strains of Staphylococcus aureus to this macrolide antibiotic revealed two peaks.
Nineteen strains (73%) were susceptible to the antibiotic at MIC of 6.3mcg/ml or less.
5) Clinical trials
Of the 20 patients of superficial infectious diseases mainly, 2 showed excellent response, 12 good. 2 unidentified and 4 failed to respond to it.
No adverse reactions were observed but one numbness at the upper limb.
