EVALUATION OF A NEW MACROLIDE ANTIBIOTIC, PROPIONYLMARIDOMYCIN, IN DERMATOLOGICAL FIELD

Abstract

Serum and skin concentrations of propionylmaridomycin were studied in rabbits.
After the oral administration of propionylmaridomycin at dose of 600 mg, the peak concentration in skin was about half the serum concentration and the peak in skin appeared after little lag of time than the peak in blood.
In vitro antibacterial activity studies on 50 clinical isolates and the clinical studies were also performed.
Most Staphylococci of the 50 clinical isolates were susceptible to propionylmaridomycin with MIC of 1.56 mcg/ml. The antibiotic susceptibility of Staphylococcus aureus 209 P was 0.78 mcg/ml of MIC.
Propionylmaridomycin demonstrated favourable effects against frunkles, MIC of which causative organism was 1.56mcg/ml or so.
However, it revealed negative effects against two folliculitis patients irrespective of the MIC of the causal organisms.