A CLINICAL STUDY ON DISTRIBUTION OF AMOXYCILLIN CONCENTRATIONS INTO THE HUMAN BLOOD AND BONE MARROW
1973 Volume 21 Issue 8 Pages 1638-1642
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1973 Volume 21 Issue 8 Pages 1638-1642
Amoxycillin, the molecular constructure of which was shown in Fig. 1, the solubility in Table 1, and the antibacterial spectrum in Table 2, was administered orally to twelve volunteers. The dosage was 500 mg and after the administration, the blood levels and the concentrations distributed into the bone marrow were assayed by band culture method (OKUBO).
The experimental results are demonstrated in Table 3, Fig. 2, and Fig. 3. The blood levels were much higher than those of ampicillin.
As for the ratio of the concentrations in the blood and bone marrow, the experimental results are indicated in Table 4; this shows that the ratio increases in the course of time after the administration.
