USE OF DIDEOXYKANAMYCIN B IN OPHTHALMOLOGY

Abstract

A new antibiotic, dideoxykanamycin B (DKB) was studied to evaluate this possible uses in ophthalmology.
1) Sensitivity of organisms isolated from human clinical materials : All staphylococci in vitro studied were sensitive to 6.25 mcg/ml or less of DKB.
DKB showed similar excellent bacteriostatic effects in vitro experiments to aminodeoxykanamycin.
2) DKB showed definitely superior penetration into the aqueous humor than aminodeoxykanamycin or kanamycin in rabbit experiments after intramuscular or subconjunctival injection.
3) DKB was administered intramuscularly at the dose of 100 mg to 7 volunteers.
The blood concentration of average value of 7 cases was 15.3 mcg/ml after 1 hour, and 3.1 mcg/ml even after 6 hours.
4) Twelve patients with extraocular infection were treated intramuscularly with daily administration of 50-100 mg of DKB.
All of these cases improved by the treatment, and no side effect was observed.