SOME EXPERIMENTS AND CLINICAL EXPERIENCE WITH 3', 4'-DIDEOXYKANAMYCIN B
1974 Volume 22 Issue 5 Pages 840-843
Details
1974 Volume 22 Issue 5 Pages 840-843
Laboratory and clinical investigations were performed on 3', 4'-dideoxykanamycin B (abbr. DKB), and the results were obtained as follows.
(1) Thirteen strains among 14 of Pseudomonas aeruginosa were inhibited the growth by 1.56-3.12 mcg/ml of DKB.
(2) Fifty mg or 100 mg of DKB were injected intramuscularly once, and a peak of blood concentration was exhibited 1 hour after the administration, showing 6 or 9 mcg/ml respectively. The above serum after 1 and 2 hours, inhibited the growth of Pseudomonas aeruginosa till 4 fold dilution. The blood concentration rose scarcely by inhalation of 50 mg of DKB dissolved in 4 ml of distilled water.
(3) The concentration of DKB in sputum did not attain 1 mcg/ml both after 50 mg or 100 mg of the drug were injected intramuscularly.
(4) DKB was administered to 5 cases of respiratory tract infection due to Pseudomonas aeruginosa combined with bronchiectasis or pulmonary tuberculosis, and the bacteria disappeared in 2 cases, while the clinical symptoms improved in 4 cases including the above. No favorable effect was obtained by inhalation of DKB.
As the side effect with DKB, 1 case complained of a tinnitus.
