FUNDAMENTAL STUDIES ON THE COMBINATION EFFECTS OF JOSAMYCIN AND BROMELAIN

ON THE FATE OF JOSAMYCIN

Abstract

Effects of bromelain on absorption, distribution and excretion of josamycin were investigated in the normal and experimentally infectious rat.
When given orally, josamycin was slowly absorbed from upper part of small intestine. Its marked. affinity of tissue was observed, and it was slowly excreted in the urine. When combined with bromelain, peaks of its plasma and organ concentrations were observed earlier than the control and it was excreted more rapidly. Affinity of kidney and spleen for josamycin was slightly greater than that of liver in view of biological activity, while affinity of liver was greater when isotopically measured. Bromelain accelerated the permeability of intestine to josamycin, and increased its passage into external fluid from intestine at alkaline pH.
It is concluded therefore that bromelain accelerates absorption of josamycin and elevates early blood. and organ levels.