RESISTANCE PATTERN TO TUBERACTINOMYCIN-N AND CROSS-RESISTANCE-RELATIONSHIPS BETWEEN TUBERACTINOMYCIN-N, LIVIDOMYCIN, CAPREOMYCIN, VIOMYCIN, KANAMYCIN, AND STREPTOMYCIN RESISTANCES OF MYCOBACTERIUM TUBERCULOSIS (H 37 Rv)

Abstract

Mycobacterium tuberculosis strain H 37 Rv has two phenotypes of TUM-N resistance; one low resistance-type and another high resistance-type. The former is resistant to 200 μg/ml level of TUM-N, CPM and VM. The latter is resistant to more than 1, 000 μg/ml level of TUM-N, CPM, VM, LVM and KM. Both types are susceptible to other antituberculous agents.
VM-resistant strains of the organism are resistant to VM, CPM and TUM-N. KM-highly resistant strains are resistant to KM, LVM and CPM, and KM-lowly resistant strains are resistant to only KM. CPM-resistant strains are resistant to CPM, VM, TUM-N and LVM. LVM-resistant strains are resistant to LVM, VM, CPM and KM. SM-resistant strains are susceptible to other agents.