Abstract
Laboratory tests were made with cephradine, then the drug was applied clinically in the field of obstetrics and gynecology, and the following results were obtained.
1) Sensitivity tests were performed with cephradine on the strains isolated clinically. Staph. aureus showed a peak of sensitivity at MIC 3. 12μ/ml. E. coli demonstrated a distribution of MIC between 6. 25-50μg/ml, and a peak of sensitivity was observed at 12.5 μ/ml, antibacterial activity being almost the sameas that of cephalexin.
2) Blood levels of cephradine were measured after an oral administration of 500 mg. Peak obtained 1 hour later was 10.5μg/ml on an average. As for faetal transfer of the drug, levels in umbilical cord were 1/2 to 1/4 of those in mother's blood, and levels in amnion water were proved too.
3) Levels in genitals were proved with cephradine, while levels in milk were generally low with cephradine similarly to those of other synthetic cephalosporins.
4) Cephradine was applied clinically in 28 cases, including pelvic infection, puerperal mastitis, urinary tract infection and others. Effective ratio obtained was 82.1% (23 cases).
5) No remarkable side effect was noticed with cephradine. No special abnormality was recognized with the drug in various tests before and after the administration.
