Abstract
The interaction of penicillins-carbenicillin and sulbenicillin-and various aminoglycoside antibiotics was studied in vitro. The mixture of each penicillin and an aminoglycoside drug was incubated at37°C for up to 48 hours and tested qualitatively by thin layer chromatography. In this precedure these penicillins and some aminoglycosides?gentamicin, 3', 4'-dideoxykanamycin B, tobramycin, kanamycin and aminodeoxykanamycin-were chemically changed. The pairing of the penicillin and amikacin, lividomycin, ribostamycin or streptomycin did not show chemically remarkable change.
Since the change of each penicillin-carbenicillin, sulbenicillin, penicillin G, ampicillin or cloxacillin-by 3', 4'-dideoxykanamycin B is remarkable, the interaction of these penicillins and aminoglycosides such as gentamicin, 3', 4'-dideoxykanamycin B, tobramycin, kanamycin and aminodeoxykanamycin would be similarly significant.
The mechanism of the interaction of penicillin and aminoglycoside is speculated that β-lactam ring would react slowly to amino group, and penicillin-aminoglycoside complex would be formed with falling of antimicrobial activity. Some molecules of penicillin would turn to penicilloic acid. The degree of interaction may depend on various structures of antibiotic molecules.
