ANTIMICROBIAL ACTIVITIES OF FOSFOMYCIN IN VITRO

Abstract

The antimicrobial activities of fosfomycin were studied in vitro. The results obtained are summarized as follows.
1. The minimum inhibitory concentrations (MIC) of fosfomycin against stock culture strains were ranged 0.2 to 50 μg/ml.
2. The MICs of fosfomycin against Staph. aureus isolated from patients were ranged 3.12 to 25 μg/ml and the peak was at 12.5 μg/ml, and the peaks of MIC against E. coli and Ps. aeruginosa were at 50μg/ ml.
3. The antimicrobial activities were more effective at low pH value, and less effective in serum added medium.