1975 Volume 23 Issue 6 Pages 2063-2072
As the results of bacteriological studies of amikacin (BB-K8) made under the same conditions in comparison with kanamycin (KM), gentamicin (GM), and 3', 4'?dideoxykanamycin B (DKB), being known as aminoglycoside antibiotics;
(1) The antimicrobial spectrum and activity of amikacin were similar to those of 3', 4'-dideoxykanamycin B (DKB).
(2) The sensitivity distribution of clinical isolates of Staphylococcus aureus was different from kanamycin.
None of amikacin-resistant strains was observed and there was no correlation with kanamycin-resistant strains.
(3) The influences of pH of medium, human serum and inoculum size on the in vitro antimicrobial activity of amikacin showed the same pattern as those in kanamycin.
(4) From the growth curve of Staphylococcus aureus with biophotometer, amikacin at the minimal inhibitory concentration was found to have a growth-inhibiting effect against Staphylococcus aureus.
(5) The in vitro combination between amikacin and synthetic penicillin type antibiotics for Pseudomonas was found to be effective.
(6) Amikacin was effective in experimental infections in vivo with kanamycin-resistant Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa as well as in vitro.
