STUDIES ON AMIKACIN (BB-K8)
1975 Volume 23 Issue 6 Pages 2096-2099
Details
1975 Volume 23 Issue 6 Pages 2096-2099
On a new aminoglycoside antibiotic, amikacin, which has been developed in Japan, the basic and clinical studies were performed, and the following results were obtained.
1. The susceptibilities of a majority of clinical isolates against amikacin were inferior to DKB and gentamicin in a degree of two-fold dilution in general.
2. The peak organ level of amikacin following intramuscular injection to mice ranked in order of kidneys and lungs. The liver level was not detectedat any time of measurements.
3. The comparison of two lots of amikacin, the one is in powder form and dissolved in lidocain hydrochloride just prior to injection and the other is the solution prepared already, was performed in cross over test. In the results of blood levels and urinary recovery, there were no significant differences bet-ween both preparations.
4. Amikacin was administered intramuscularly to one case with pyelonephritis due to Pseudomonas aeruginosa, and the result was described.
