CLINICAL EFFECTIVENESS OF AMIKACIN (BB-K8) ON URINARY TRACT INFECTIONS

Abstract

1) Amikacin (BB-K8) was administered intramuscularly to 104 cases of urinary tract infections consisting of outpatients and inpatients from the Department of Urology of the University of Kyushu and their related hospitals.
Dropout was seen in two, so that 102 cases were subjected to the treatment.
2) Out of 36 cases of acute simple urinary tract infections (cystitis in 23, and pyelonephritis in 13), in 25 amikacin was administered intramuscularly at a dose of 200 mg once a day for 5 days, in 4 at a dose of 200 mg once a day for 3 days, in 4 at a dose of 100 mg twice a day for 5 days and in 3 at a dose of 400 mg once a day for 5 days.
Out of 63 cases of complicated urinary tract infections (complicated cystitis in 33, postoperative cystitis in 16, complicated pyelonephritis in 14 and postoperative pyelonephritis in 3), in 51 amikacin was administered intramuscularly at a dose of 100 mg twice a day for 5 days and in 12 at a dose of 200 mg twice a day for 5 days.
Out of 3 cases of prostatitis, in 2 amikacin was administered intramuscularly at a dose of 100 mg twice a day for 5 days and in 1 at a dose of 200 mg twice a day for 5 days.
3) The global clinical results were seen to be excellent in 46, good in 21 and poor in 35, its effectiveness rate being 66%.
4) In 36 cases of acute simple urinary tract infections, the results were seen to be excellent in 24, good in 6 and poor in 6, its effectiveness rate being 83%. In 63 cases of complicated urinary tract infections, the results were seen to be excellent in 21, good in 14 and poor in 28, its effectiveness rate being 56%. In 3 cases of prostatitis, the results were seen to be excellent in 1, good in 1 and poor in 1, respectively.
5) It was impossible to compare between the clinical results on the basis of doses because the number of cases in the 400 mg/day dosing group was small, being 16 cases, but in complicated urinary tract infections the clinical results of amikacin at a dose of 400 mg were not so good.
6) Pain at the injected area was seen in 2. In 56 cases recorded their hematological findings (hemoglobin, RBC, WBC, BUN, creatinine, GOT and GPT) transiently, no abnormal changes due to the administration of the drug were observed. No other significant side-effects were observed.
7) Amikacin (BB-K8) proved to be useful for not only acute simple urinary tract infections but also complicated urinary tract infections. Concerning the dose and duration of amikacin, however, the need of further careful examinations is keen felt.