1975 Volume 23 Issue 8 Pages 2585-2588
This study was undertaken to compare the changes in the enteric microflora of rhesus monkeys following oral dosing of bicyclomycin, ampicillin and kanamycin at 20 mg/kg twice daily for 25 days.
The numbers of aerobic and anaerobic bacteria in the various parts of the intestinal tract were not markedly changed by the repeated doses of bicyclomycin as well as ampicillin, and normal feces were excreted over the administration period of these antibiotics.
However, on the first day following the same dosing of kanamycin, the numbers of Bacteroides and Fusobacterium were markedly reduced in the intestines of all monkeys tested and severe diarrhea was observed.
