TOXICOLOGICAL STUDIES ON PIPEMIDIC ACID

II. SUBACUTE AND CHRONIC TOXICITY STUDIES IN RATS

Abstract

Subacute and chronic toxicity studies on pipemidic acid (PPA) were performed in male and female rats.
In rats given PPA at daily oral doses of 100, 300, 1, 000, 3, 000 and 5, 000 (male only) mg/kg/day for 30 days, no abnormalities were observed except for a slight decrease in weights of heart, liver and thymus, and the dilatation of cecum at high doses. The decrease in organ weight was not accompanied by histopathological abnormalities, and the dilatation of cecum was similar to that commonly observed after long-term administration of antibiotics.
In rats given PPA at daily oral doses of 50, 200, 800 and 3, 200 mg/kg/day for 6 months, no abnormalities were observed except for a slight variation in body weight gain and the dilatation of cecum. These results indicate that the oral toxicity of PPA is low in rats.