1975 Volume 23 Issue 9 Pages 2900-2905
Antibacterial activity of pipemidic acid (PPA) was examined in 70 clinical isolates of Shigella sp. All isolates were inhibited by 1.56 μg of the drug per ml except for one resistant strain. Compared to nalidixic acid (NA) and piromidic acid (PA), PPA was 2 to 4 times more potent than NA and 8 to 16 times more potent than PA. PPA was not completely cross-resistant with the other two drugs.
Clinical results, when PPA was administered mostly at 1 to 2g for 5 days, were effective in 18 of 20 cases of bacillary dysentery, ineffective in 1 and unknown in 1, the efficacy rate being 94. 7 %. Causative bacteria were eliminated in 17 of 19 cases, the elimination rate being 89. 5 %. Of 13 carriers of dysentery bacilli, effectiveness was observed except for one showing re-appearance of the infecting organism. Among the other dysentery-like diseases, PPA showed excellent effect in 3 cases of food poisoning due to Vibrio parahaemolyticus, but failed to eliminate the infecting organism in 1 carrier of Salmonella sp. at a daily dose of 1. 5 g for 15 days. In 13 cases where causative organisms were not able to be detected, 12 were effective and 1 ineffective. It was found that the sensitivity of the infecting organisms to PPA and NA became lower when they re-appeared after treatment with the former drug in 2 cases of bacillary dysentery.
Side effects were not observed subjectively and objectively in all cases. In 2 cases showing high S-GOT and S-GPT levels, these levels were normalized after medication in one and remained
