1976 Volume 24 Issue 4 Pages 909-916
1) There were no differences in the distribution of MIC between Ceftezole (CTZ) and Cefazolin (CEZ) against both 100 stock strains of Staph. aureus and Staph. epidermidis. MIC of CEZ against 100 stock strains of E. call was distributed to be lower concentration than that of CTZ.
2) From the results of MIC test against clinically isolated strains by the disc method, it could hardly be concluded that the antimicrobial activity of CTZ was specifically more effective than that of CEZ. The numbers of CTZ sensitive strains were slightly more than that of CEZ sensitive ones in the Gram negative bacteria, particularly Klebsiella.
3) From the determination of effective concentration of CTZ in the blood and urine, the intramuscular injection of CTZ lg twice a day was enough in the treatment of the urinary tract infection and other infections diseases needed the intramuscular injection of CTZ Ig 3 times a day.
4) Clinical effects of CTZ were studied in the followed 17 patients. Three cases in the urinary tract infection, 11 cases in the respiratory tract infection and 1 case of the Peptococcus sepsis could be cured by the injection of CTZ. But in the treatment of another 2 patients with the respiratory tract infection, the effect of CTZ is not found in 1 case and could not be determined in another case. No side effects were observed except one case in which eruption was noticed.
5) The clinical course of HB-Ag associated acute hepatitis was not changed by the administration of CTZ.
